Incomplete cre-mediated excision leads to phenotypic differences betweenStra8-iCre; Mov10l1lox/loxandStra8-iCre; Mov10l1lox/Δmice
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منابع مشابه
hCD2-iCre and Vav-iCre Mediated Gene Recombination Patterns in Murine Hematopoietic Cells
Cre-recombinase mediated conditional deletion of Lox-P site flanked ("floxed") genes is widely used for functional gene annotation in mice. Many different Cre-transgenic mouse lines have been developed for cell-type specific gene disruption. But often, the precise tissue-patterns of Cre activity remain incompletely characterized. Two widely used transgenes for conditional gene recombination in ...
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UNLABELLED Engineering viral vectors to produce liver-specific protein expression may help advance understanding of hepatic regeneration and disease states. In addition to introducing genes of interest to the liver, these vectors can be adapted for gene deletion when designed to express Cre recombinase. The ability to use this system requires high, liver-restricted expression, low toxicity, and...
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ژورنال
عنوان ژورنال: genesis
سال: 2013
ISSN: 1526-954X
DOI: 10.1002/dvg.22389